Response, disease-free interval and overall survival of cats with nasal planum squamous cell carcinoma treated with a fractionated vs a single-dose protocol of strontium plesiotherapy.

Abstract

OBJECTIVES:

The main aim of the study was to establish response, disease-free interval (DFI) and overall survival of cats with nasal planum squamous cell carcinoma (SCC) treated with Sr90 plesiotherapy. A secondary aim was to determine whether a fractionated protocol is more effective than a single-dose protocol in terms of response, DFI and overall survival. The third aim was to evaluate whether we can identify prognostic factors that influence overall survival.

METHODS:

This was a retrospective study that included cats with a diagnosis of nasal planum SCC treated with Sr90 plesiotherapy at a single institution.

RESULTS:

Seventy-four cats were included in the study. Thirty-two were treated with a fractionated protocol and 42 with a single-dose treatment. Sr90 plesiotherapy was able to induce complete response in 74% of cats with nasal planum SCC. The median DFI was 780 days (95% confidence interval [CI] 383-1177), with 17% of cats experiencing local recurrence. The overall survival for all cats was 1039 days (95% CI 55-1528). The DFI of cats treated with the fractionated Sr90 was significantly longer compared with the single-dose treatment, whereas response and overall survival were not statistically different. Other prognostic factors that influenced the overall survival were early-stage disease, absence of concurrent problems and complete response to the treatment. Acute and long-term toxicity associated with the treatment were minimal and the aesthetic outcome was pleasing in almost all cases.

CONCLUSIONS AND RELEVANCE:

Strontium plesiotherapy is a safe and effective treatment of nasal planum SCC in cats.

• Authors: Davide Berlato, Sue Murphy, Silja Laberke, Sara Verganti
• Journal: Journal of feline medicine and surgery (J Feline Med Surg) Vol. 21 Issue 4 Pg. 306-313 (04 2019) ISSN: 1532-2750 [Electronic] England
• PMID: 29788830 (Publication Type: Journal Article)

Chemical References

• Strontium Radioisotopes
• Strontium-90

Topics

• Animals
• Carcinoma, Squamous Cell (mortality, radiotherapy, veterinary)
• Cat Diseases (mortality, radiotherapy)
• Cats
• Disease-Free Survival
• Dose Fractionation, Radiation
• Nose Neoplasms (mortality, radiotherapy, veterinary)
• Retrospective Studies
• Strontium Radioisotopes (therapeutic use)