High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma.

Abstract

NSUN2 is a tRNA methyltransferase and plays an important role in cell development via modifying RNA methylation. We aimed to evaluate the expression of NSUN2 and its prognostic value in HNSCC. Random-effects model of meta-analysis shows 1.99-folds (95% CI: 1.89-2.09) upregulation of NSUN2 expression in HNSCC versus normal tissues. Patients with high NSUN2 levels had approximately 22 months shorter overall survival, and had a higher mortality risk than those with low one (p-trend = 0.020). In conclusion, NSUN2 is a potential independent prognostic marker and may be a potential therapeutic target in HNSCC.

• Authors: Lingeng Lu, Gongjian Zhu, Hongmei Zeng, Qian Xu, Klaus Holzmann
• Journal: Cancer investigation (Cancer Invest) Vol. 36 Issue 4 Pg. 246-253 (Apr 21 2018) ISSN: 1532-4192 [Electronic] England
• PMID: 29775108 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Methyltransferases
• NSUN2 protein, human

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (enzymology, genetics, mortality)
• Female
• Gene Expression
• Head and Neck Neoplasms (enzymology, genetics, mortality)
• Humans
• Kaplan-Meier Estimate
• Male
• Methyltransferases (biosynthesis, genetics)
• Middle Aged
• Prognosis
• Proportional Hazards Models
• Squamous Cell Carcinoma of Head and Neck
• Young Adult