Use of febantel or ivermectin for treatment of calves with experimentally induced Bunostomum phlebotomum infection.

Abstract

In the first of 2 separate trials, the efficacy of febantel, given at a dosage of 5 mg/kg of body weight, was assessed in calves with 60-day experimentally induced Bunostomum phlebotomum infection. Ten calves were given febantel paste, and 10 were given the vehicle only. All 20 calves were necropsied 7 days after cessation of treatment. Compared with untreated calves, febantel-treated calves harbored 99.4% fewer nematodes. In the second trial, the efficacy of ivermectin, given as a paste formulation at a dosage of 0.2 mg/kg, was assessed in calves with experimentally induced B phlebotomum infection. Ivermectin was given at 18 (n = 6) and 60 (n = 6) days after infection. At each treatment date, 3 additional calves were given vehicle only. At 67 days after infection, all calves were euthanatized. Efficacies of ivermectin against 18- and 60-day infections were 100 and 99.8%, respectively. Both anthelmintic preparations were easily administered, and adverse reactions were not observed.

• Authors: T A Yazwinski
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 49 Issue 8 Pg. 1407-8 (Aug 1988) ISSN: 0002-9645 [Print] United States
• PMID: 2972237 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Guanidines
• Ivermectin
• febantel

Topics

• Ancylostomatoidea (drug effects, isolation & purification)
• Animals
• Cattle
• Cattle Diseases (drug therapy)
• Guanidines (therapeutic use)
• Hookworm Infections (drug therapy, parasitology)
• Ivermectin (therapeutic use)