Abstract | BACKGROUND: OBJECTIVE: METHODS: Mice pretreated with IMP (5, 10 mg/kg po) were administered LPS (250 μg/kg ip) for 7 days. Memory was evaluated in the Morris water maze (MWM) and Y maze. The mice were euthanised and different biochemical assessments were carried out to measure oxidative stress and acetyl choline esterase (AChE). Further, evaluation of proinflammatory cytokines such as tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) levels and brain derived neurotrophic factor ( BDNF) in hippocampus and cortex of brain were performed. RESULTS: LPS administration caused poor memory retention in both, MWM and Y maze, and caused distinct oxidative stress since decrease in superoxide dismutase (SOD), reduced glutathione (GSH) levels and increased lipid peroxidation were observed. Also, a significant rise was observed in the levels of AChE. Moreover, a rise in TNF-α and IL-6 levels and depleted levels of BDNF were noted. IMP pretreatment reversed LPS induced behavioral and memory disturbances and significantly decreased the oxidative stress and AChE levels. It also reduced TNF-α and IL-6 levels and caused a significant upregulation of BDNF levels. CONCLUSION:
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Authors | Amrita A Chowdhury, Nitin B Gawali, Prashant Shinde, Renuka Munshi, Archana R Juvekar |
Journal | Cytokine
(Cytokine)
Vol. 110
Pg. 78-86
(10 2018)
ISSN: 1096-0023 [Electronic] England |
PMID | 29705395
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
- Bdnf protein, mouse
- Brain-Derived Neurotrophic Factor
- Cytokines
- Furocoumarins
- Interleukin-6
- Lipopolysaccharides
- Tumor Necrosis Factor-alpha
- Superoxide Dismutase
- Glutathione
- imperatorin
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Topics |
- Animals
- Anxiety
(drug therapy, metabolism)
- Brain-Derived Neurotrophic Factor
(metabolism)
- Cerebral Cortex
(drug effects, metabolism)
- Cytokines
(metabolism)
- Disease Models, Animal
- Epilepsy
(drug therapy, metabolism)
- Furocoumarins
(pharmacology)
- Glutathione
(metabolism)
- Hippocampus
(drug effects, metabolism)
- Interleukin-6
(metabolism)
- Lipid Peroxidation
(drug effects)
- Lipopolysaccharides
(pharmacology)
- Male
- Maze Learning
(drug effects)
- Memory
(drug effects)
- Memory Disorders
(chemically induced, metabolism)
- Mice
- Oxidative Stress
(drug effects)
- Superoxide Dismutase
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
- Up-Regulation
(drug effects)
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