Hybrid MoSe2-indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy.

Abstract

Phototheranostic technology based on photoacoustic imaging (PAI) and photothermal therapy (PTT) is emerging as a powerful tool for tumor theranostic applications. For effective tumor eradication, a novel PAI/PTT theranostic nanoagent with an excellent optical absorption and photothermal capability is highly desired. Herein, we present a new PAI/PTT nanohybrid named sMoSe2-ICG NSs by covalently conjugating aminated indocyanine green (ICG) onto a single layer of molybdenum selenide nanosheets (sMoSe2 NSs). We first validate the sMoSe2-ICG NS agent for the PAI and PTT effect in vitro and then use it for highly-sensitive PAI guided highly efficient tumor PTT in vivo. The sMoSe2-ICG NS hybrid possesses several advantages for PAI/PTT applications: (1) the sMoSe2-ICG NSs have strong absorbance in the broad near-infrared (NIR) region, enabling a highly efficient PAI/PTT theranostic effect and the selection of the most widely used excitation wavelength of 808 nm for PTT; (2) the photothermal ability of ICG in sMoSe2-ICG NSs is augmented due to ICG aggregation induced fluorescence quenching and the re-absorbance of ICG fluorescence by sMoSe2 NSs, which further enhances the PAI/PTT theranostic effect. (3) The characteristic absorption peak of sMoSe2-ICG NSs is red-shifted compared to free ICG, resulting in a higher PAI signal-to-noise ratio (SNR) in vivo. Thus, combined with the good stability, high biocompatibility and minimal toxicity properties, the obtained sMoSe2-ICG NSs hybrid has bright prospects for use in future PAI/PTT clinical applications.

• Authors: Jingqin Chen , Xueshen Li , Xiaoyang Liu , Huixiang Yan , Zhihua Xie , Zonghai Sheng , Xiaojing Gong , Lidai Wang , Xin Liu , Peng Zhang , Hairong Zheng , Liang Song , Chengbo Liu
• Journal: Biomaterials science (Biomater Sci) Vol. 6 Issue 6 Pg. 1503-1516 (May 29 2018) ISSN: 2047-4849 [Electronic] England
• PMID: 29633765 (Publication Type: Journal Article)

Chemical References

• Coloring Agents
• Molybdenum
• Selenious Acid
• Indocyanine Green

Topics

• Animals
• Breast Neoplasms (diagnostic imaging, therapy)
• Coloring Agents (therapeutic use)
• Female
• Hyperthermia, Induced (methods)
• Indocyanine Green (therapeutic use)
• Mice, Inbred BALB C
• Mice, Nude
• Molybdenum (chemistry, therapeutic use)
• Nanostructures (therapeutic use)
• Optical Imaging (methods)
• Photoacoustic Techniques (methods)
• Phototherapy (methods)
• Selenious Acid (chemistry, therapeutic use)
• Theranostic Nanomedicine (methods)