Interleukin-10 as a novel biomarker of metabolic risk factors.

Abstract

BACKGROUND:

Interleukin-10 (IL-10) is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of interleukin-10 with the number of metabolic risk factors.

FINDING:

The study population comprised 220 children who underwent annual health checkups. Plasma Interleukin-10 levels were determined by enzyme-linked immunosorbent assay. We divided the subjects into 4 groups according to Interleukin-10 levels. A reduction of plasma interleukin-10 levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, BMI, dyslipidaemia, high blood pressure and glucose intolerance.

CONCLUSIONS:

Circulating Interleukin-10 levels negatively correlated with the multiplicity of metabolic risk factors, suggesting that IL-10 acts as a biomarker of metabolic disorders.

• Authors: Himani Kulshrestha, Vani Gupta, Sameeksha Mishra, Abbas Ali Mahdi, Shelly Awasthi, Sandeep Kumar
• Journal: Diabetes & metabolic syndrome (Diabetes Metab Syndr) Vol. 12 Issue 4 Pg. 543-547 (Jul 2018) ISSN: 1878-0334 [Electronic] Netherlands
• PMID: 29615317 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers
• IL10 protein, human
• Interleukin-10

Topics

• Adolescent
• Biomarkers (blood)
• Body Mass Index
• Case-Control Studies
• Child
• Child, Preschool
• Dyslipidemias (blood, diagnosis, etiology)
• Female
• Follow-Up Studies
• Glucose Intolerance (blood, diagnosis, etiology)
• Humans
• Interleukin-10 (blood)
• Intra-Abdominal Fat
• Male
• Metabolic Syndrome (blood, diagnosis, etiology)
• Obesity (complications)
• Prognosis
• Risk Factors