Sonodynamic therapy-assisted immunotherapy: A novel modality for cancer treatment.

Abstract

Sonodynamic therapy (SDT), which is based on photodynamic therapy (PDT), is a new cancer treatment modality. Unlike PDT, which has poor tissue penetration, ultrasound can penetrate deeply into tissues and largely target tumor tissue to mediate the cytotoxicity of sonosensitizers. We hypothesize that, similar to PDT, SDT may perform effectively as a cancer vaccine. Thus, we developed a therapeutic strategy to explore whether SDT can eliminate primary tumors, inhibit metastases, and prevent tumor relapse. In the present study, we found that HiPorfin (HPD)-induced SDT killed tumor cells, promoted calreticulin expression on the cell surface and elicited immune responses. Meanwhile, we observed that SDT induced functional antitumor vaccination and abscopal effects in H22 tumor-bearing mice. Furthermore, this strategy conferred an immunological memory, which could protect against tumor recurrence after the elimination of the initial tumor. These results showed important effects of SDT on immune responses.

• Authors: Qianyu Zhang, Cuixia Bao, Xiaojun Cai, Longwei Jin, Lingling Sun, Yuehong Lang, Libo Li
• Journal: Cancer science (Cancer Sci) Vol. 109 Issue 5 Pg. 1330-1345 (May 2018) ISSN: 1349-7006 [Electronic] England
• PMID: 29575297 (Publication Type: Journal Article)
• Copyright: © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Chemical References

• CALR protein, human
• Calreticulin
• Metalloporphyrins
• Photosensitizing Agents

Topics

• Animals
• Calreticulin (metabolism)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Combined Modality Therapy
• Humans
• Immunotherapy
• Liver Neoplasms (immunology, metabolism, therapy)
• Metalloporphyrins (administration & dosage, pharmacology)
• Mice
• Photochemotherapy
• Photosensitizing Agents
• Ultrasonic Therapy (methods)