Abstract | BACKGROUND AND AIMS: METHODS: RESULTS: Overall, 587 patients were included in the study. At ultrasonography, 380 patients had carotid atherosclerosis (64.7%) and 45 internal carotid (ICA) stenosis ≥50% (7.7%). During a mean follow-up of 41 ± 15 months, 30 patients had an ischemic stroke or TIA (1.49% per patient-year, 95% CI 0.96-2.03) and 81 patients died (4.01% per patient-year, 95% CI 3.16-4.86). Carotid atherosclerosis was associated with a significant increase in the risk for the composite of ischemic stroke or TIA or death after adjusting for CHA2DS2VASc (6.0% vs. 3.1% patient-year; HR 1.60, 95% CI 0.99-2.59; p = 0.05). ICA ≥50% was associated with a not significant increase in the risk of ischemic stroke or TIA (2.05% vs. 1.45% patient-year; HR 1.39, 95% CI 0.42-4.58) or all-cause death (6.1% vs. 3.8% patient-year; HR 1.66, 95% CI 0.83-3.32). CONCLUSIONS:
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Authors | Cecilia Becattini, Francesco Dentali, Giuseppe Camporese, Agnese Sembolini, Elena Rancan, Chiara Tonello, Giorgia Manina, Seena Padayattil, Giancarlo Agnelli |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 271
Pg. 177-181
(04 2018)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 29524860
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Administration, Oral
- Aged
- Aged, 80 and over
- Anticoagulants
(administration & dosage, adverse effects)
- Atrial Fibrillation
(diagnosis, drug therapy, mortality)
- Brain Ischemia
(diagnosis, epidemiology, mortality, prevention & control)
- Carotid Stenosis
(diagnostic imaging, epidemiology, mortality)
- Female
- Humans
- Ischemic Attack, Transient
(diagnosis, epidemiology, mortality, prevention & control)
- Italy
(epidemiology)
- Male
- Middle Aged
- Prevalence
- Prospective Studies
- Risk Assessment
- Risk Factors
- Stroke
(diagnosis, epidemiology, mortality, prevention & control)
- Time Factors
- Treatment Outcome
- Ultrasonography, Doppler
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