High serum procalcitonin levels in patients with periodontitis and chronic migraine.

Abstract

BACKGROUND:

To evaluate the contribution of chronic periodontitis (CP) to serum procalcitonin (proCT) levels in chronic migraine (CM) patients in a cross-sectional study.

METHODS:

We included 138 subjects divided into 4 groups based on clinical features of CM and periodontal parameters: systemically and periodontally healthy individuals (n = 37), systemically healthy and CP patients (n = 19), CM and periodontally healthy patients (n = 34), and CM+CP patients (n = 48). Demographic, neurological, clinical data as well as full-mouth periodontal records were obtained. ProCT and high sensitive C-reactive protein (hs-CRP) serum levels were determined from blood samples taken during migraine interictal period.

RESULTS:

Patients from the CP+CM group (0.056±0.006 ng/mL) had significantly higher serum proCT levels in comparison with the systemically and periodontally healthy group (0.029±0.019 ng/mL), CM group (0.041±0.002 ng/mL), or CP group (0.034±0.014 ng/mL) (p < 0.001). There were no significant differences in hs-CRP between groups (p = 0.081). Multiple linear regression analysis showed that CP was associated with increased proCT levels in CM patients (R2  = 0.293, p < 0.001).

CONCLUSIONS:

CP independently contributes to elevated serum proCT levels in CM patients. These findings suggest that CP could play a role in migraine chronification.

• Authors: Yago Leira, Pablo Ameijeira, Clara Domínguez, Rogelio Leira, Juan Blanco
• Journal: Journal of periodontology (J Periodontol) Vol. 89 Issue 9 Pg. 1069-1074 (09 2018) ISSN: 1943-3670 [Electronic] United States
• PMID: 29520793 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 American Academy of Periodontology.

Chemical References

• Procalcitonin

Topics

• Chronic Periodontitis
• Cross-Sectional Studies
• Humans
• Migraine Disorders
• Periodontal Index
• Procalcitonin