Abstract |
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is an innovative molecular imaging technique in which contrast agents are labeled by saturating their exchangeable proton spins by radio-frequency irradiation. Salicylic acid and its analogues are a promising class of highly sensitive, diamagnetic CEST agents. Herein, polymeric agents grafted with salicylic acid moieties and a known high-affinity ligand targeting prostate-specific membrane antigen in approximately 10:1 molar ratio were synthesized to provide sufficient MRI sensitivity and receptor specificity. The proton-exchange properties of the contrast agent in solution and in an experimental murine model are reported to demonstrate the feasibility of receptor-targeted CEST MRI of prostate cancer. Furthermore, the CEST imaging data were validated with an 111 In-labeled analogue of the agent by in vivo single photon emission computed tomographic imaging and tissue biodistribution studies.
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Authors | Sangeeta Ray Banerjee, Xiaolei Song, Xing Yang, Il Minn, Ala Lisok, Yanrong Chen, Albert Bui, Samit Chatterjee, Jian Chen, Peter C M van Zijl, Michael T McMahon, Martin G Pomper |
Journal | Chemistry (Weinheim an der Bergstrasse, Germany)
(Chemistry)
Vol. 24
Issue 28
Pg. 7235-7242
(May 17 2018)
ISSN: 1521-3765 [Electronic] Germany |
PMID | 29508450
(Publication Type: Journal Article)
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Copyright | © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Contrast Media
- Polymers
- Protons
- Salicylic Acid
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Topics |
- Animals
- Contrast Media
(chemistry)
- Humans
- Magnetic Resonance Imaging
- Male
- Polymers
(chemistry)
- Prostatic Neoplasms
(diagnostic imaging)
- Protons
- Salicylic Acid
(chemistry)
- Tissue Distribution
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