Abstract | OBJECTIVES: METHODS: An acute acoustic trauma was performed to 13 guinea pigs for a period of 1 h on Day -2. Two 2 days after the noise trauma, the animals were then assigned randomly to four experimental groups: control without gel, gel injection, gel-containing free DexP, gel-containing DexP loaded into liposomes. Auditory thresholds were measured with Auditory Brainstem Response before Day -2 and at Day 0, Day 7 and Day 30 after noise trauma. RESULTS: Seven days after, a complete hearing recovery was observed in the control group at all frequencies apart from 8 kHz, and no recovery was observed in the three groups receiving a gel injection. Thirty days after trauma, all of the animals had recovered normal hearing, apart from at the 8-kHz frequency, with similar auditory thresholds. CONCLUSIONS: Local DexP administration 48 h after a mild acoustic trauma did not improve hearing recovery, even with a sustained release in a specific gel formulation designed for inner ear therapy.
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Authors | Elisabeth Mamelle, Naila El Kechai, Victor Adenis, Yann Nguyen, Olivier Sterkers, Florence Agnely, Amélie Bochot, Jean Marc Edeline, Evelyne Ferrary |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 138
Issue 7
Pg. 610-616
(Jul 2018)
ISSN: 1651-2251 [Electronic] England |
PMID | 29504828
(Publication Type: Journal Article)
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Chemical References |
- Glucocorticoids
- Liposomes
- Dexamethasone
- Hyaluronic Acid
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Topics |
- Animals
- Dexamethasone
(administration & dosage)
- Drug Evaluation, Preclinical
- Glucocorticoids
(administration & dosage)
- Guinea Pigs
- Hearing Loss, Noise-Induced
(drug therapy)
- Hyaluronic Acid
- Liposomes
- Male
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