[Clinical Study of 2014 ISUP New Grade Group Classification for Prostate Cancer Patients Treated by Androgen Deprivation Therapy].

Abstract

The 2014 International Society of Urological Pathology (ISUP) has proposed a new grade group (GG) classification for Gleason scores (GS). The usefulness of the new GG classification was investigated with 518 prostate cancer patients who underwent androgen deprivation therapy. According to the new GG classification, Stages B‒D and the new GG classification relapse-free rate for each stage were calculated using the Kaplan‒Meier method. The new GG classification revealed a significant difference for the relapse-free rate only between some groups. Analysis using the Cox proportional hazards model indicated that the risk of relapse was higher in GGs 4 and 5 than in GG 1. The usefulness about the relapse-free rate in androgen deprivation therapy of the 2014 ISUP new grade group classification a waits future examination.

• Authors: Masahiro Uno, Makoto Kawase, Daiki Kato, Takashi Ishida, Seiichi Kato, Yoshinori Fujimoto
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 64 Issue 1 Pg. 7-11 (Jan 2018) ISSN: 0018-1994 [Print] Japan
• PMID: 29471597 (Publication Type: Journal Article)

Chemical References

• Androgen Antagonists
• Androgens

Topics

• Aged
• Aged, 80 and over
• Androgen Antagonists (therapeutic use)
• Androgens (metabolism)
• Humans
• Male
• Middle Aged
• Neoplasm Grading
• Prostatic Neoplasms (diagnosis, drug therapy)