Abstract | BACKGROUND: MATERIAL AND METHODS: This study was based on data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database. We included 2173 patients with RC who received neoadjuvant therapy. Restricted cubic spline was used to analyze the association between eLNs and lymph node metastasis (LNM). RESULTS: The number of eLNs was an independent predictive factor for the presence of LNM (odds ratio 1.033; 95% confidence interval 1.020-1.046; P < 0.001). When the number of eLN ≤ 16, 10 and 11 eLNs had the highest rates of positive LNM. Analysis of the restricted cubic spline method found that when number of eLNs was < 10, the LNM rate increased rapidly, but this increase was not so obviously when there were > 10 eLNs. CONCLUSIONS: Among RC patients who receive neoadjuvant therapy, the minimum number of eLNs may be 10 to ensure pathological quality.
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Authors | Peng Gao, Yongxi Song, Yuchong Yang, Shan Zhao, Yu Sun, Jingxu Sun, Xiaowan Chen, Zhenning Wang |
Journal | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
(J Gastrointest Surg)
Vol. 22
Issue 6
Pg. 1068-1076
(06 2018)
ISSN: 1873-4626 [Electronic] United States |
PMID | 29468556
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Aged, 80 and over
- Female
- Humans
- Lymph Node Excision
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Male
- Medicare
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Staging
- Rectal Neoplasms
(pathology, therapy)
- SEER Program
- United States
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