Abstract | RATIONALE: PATIENT CONCERNS: A previously healthy immunocompetent 9-year-old girl first presented with seizures, headaches and vomiting. Cerebrospinal fluid and brain magnetic resonance imaging were normal. After one week onset, the patient gradually developed unexplained personality and behavior changes, accompanied by fever and seizures again. Repeated CSF analysis revealed a slightly lymphocytic predominant pleocytosis and positive anti-NMDAR antibody. A variety of pathogenic examinations were negative, except for positive toxoplasma IgM and IgG. DIAGNOSES: INTERVENTIONS: The patient received 10 days azithromycin for treatment of acquired toxoplasma infection. The parents refuse immunotherapy because substantial recovery from clinical symptoms. OUTCOMES: The patient was substantially recovered with residual mild agitation after therapy for acquired toxoplasma gondii infection. Two months later, the patient was completely devoid of symptoms, and the levels of serum IgM and IgG of toxoplasma gondii were decreased. LESSONS:
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Authors | Xiaotang Cai, Hui Zhou, Yongmei Xie, Dan Yu, Zhiling Wang, Haitao Ren |
Journal | Medicine
(Medicine (Baltimore))
Vol. 97
Issue 7
Pg. e9924
(Feb 2018)
ISSN: 1536-5964 [Electronic] United States |
PMID | 29443773
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antiprotozoal Agents
- Immunoglobulin G
- Immunoglobulin M
- Azithromycin
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Topics |
- Anti-N-Methyl-D-Aspartate Receptor Encephalitis
(diagnosis, drug therapy, parasitology)
- Antiprotozoal Agents
(therapeutic use)
- Azithromycin
(therapeutic use)
- Child
- Female
- Humans
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Toxoplasma
(immunology)
- Toxoplasmosis, Cerebral
(diagnosis, drug therapy)
- Treatment Outcome
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