Ocular surface squamous neoplasia in a setting of fungal keratitis: a rare co-occurrence.

Abstract

PURPOSE:

To describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis.

METHODS:

Case report.

RESULTS:

We describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven severe fungal keratitis of 5 months duration, which progressed to endophthalmitis. She was managed with extended enucleation for left eye. Histopathology examination was consistent with squamous cell carcinoma of ocular surface with no corneal stromal/scleral/anterior chamber involvement. She received adjuvant chemotherapy with topical Interferon alpha2b (3 cycles) for positive margins. Six months after treatment, she is completely tumor free.

CONCLUSION:

Co-occurrence of OSSN and chronic fungal keratitis is rare. We recommend that patients with chronic ocular infections should be examined and followed closely for abnormally thickened limbal areas.

• Authors: Swati Singh, Ruchi Mittal, Purvasha Narang, Vikas Mittal
• Journal: International ophthalmology (Int Ophthalmol) Vol. 39 Issue 3 Pg. 717-720 (Mar 2019) ISSN: 1573-2630 [Electronic] Netherlands
• PMID: 29423784 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents

Topics

• Aged
• Antifungal Agents (therapeutic use)
• Biological Dressings
• Biopsy
• Carcinoma, Squamous Cell (complications, diagnosis)
• Conjunctival Neoplasms (complications, diagnosis, surgery)
• Eye Infections, Fungal (complications, diagnosis, drug therapy, surgery)
• Female
• Humans
• Keratitis (complications, diagnosis, drug therapy)
• Laser Coagulation