TACE (transcatheter arterial chemoembolization) has been recognized as an effective
palliative treatment option for patients with HCC, however, the medium-long term efficacy of it remains modest.
LY2109761, a TGF-β receptor inhibitor, was confirmed to reduce
tumor cell growth, intravasation, and metastatic dissemination of HCC cells through different molecular mechanisms. This study aims to investigate the treatment effect of combining TACE
therapy with LY2109761- a TGF-β receptor I
kinase inhibitor on suppressing
tumor growth and
metastasis in a rabbit VX2
tumor model. The molecular mechanisms underlying the
biological activities of
LY2109761 was also evaluated through an in vitro model. And we found that
LY2109761 could inhibit cell proliferation by down-regulating the phosphorylation of Smad-2 as well as improved the
therapeutic effect of TACE in a VX2
hepatocellular carcinoma model. And we further found that
LY2109761 may play a modulating role in the process of T cell transformation. Hence, based on those obsevations in our research, we concluded that combing
LY2109761 with TACE for the treatment of VX2 rabbit
liver cancer can help inhibit
tumor growth as well as increase the
tumor cell
necrosis after TACE.