Functional Neuroanatomy of Secondary Self-Injurious Behavior.

Abstract

BACKGROUND:

Secondary self-injurious behavior (SSIB) is underreported and predominantly not associated with suicide. In both adults and children, SSIB can cause intractable self-harm and is associated with a variety of clinical disorders, particularly those involving dysfunctional motor control.

METHODS:

We performed a literature review evaluating the clinical efficacy of deep-brain stimulation (DBS) as modulating SSIB observations and review current progress in preclinical SSIB animal studies.

RESULTS:

Neuromodulation is an effective therapeutic option for several movement disorders. Interestingly, this approach is emerging as a potentially effective treatment for movement disorder-associated SSIB (secondary); however, it is important to understand the neuroanatomy, clinical appraisal, and outcome data when considering surgical therapy for SSIB.

CONCLUSION:

The current review examines the literature encompassing animal models and human case studies while identifying existing hypotheses from cytoarchitectonic-based targeting to neurotransmitter-based pathways. This review also highlights the need for awareness of an underrecognized pathology that may be amenable to DBS.

• Authors: Sophie Peeters, Jesse Skoch, Hiromi Holt, Lynn Mubita, Eileen A Choudhary, Kavan P Vadivelu, Donald L Gilbert, Steve W Wu, Alaine C Keebaugh, Ellen Air, Sudhakar Vadivelu
• Journal: Pediatric neurosurgery (Pediatr Neurosurg) Vol. 53 Issue 2 Pg. 71-80 ( 2018) ISSN: 1423-0305 [Electronic] Switzerland
• PMID: 29402877 (Publication Type: Journal Article, Review)
• Copyright: © 2018 S. Karger AG, Basel.

Topics

• Animals
• Basal Ganglia
• Brain (anatomy & histology, physiology)
• Deep Brain Stimulation (methods)
• Humans
• Mental Disorders (therapy)
• Movement Disorders (physiopathology, therapy)
• Neuroanatomy
• Pediatrics
• Self-Injurious Behavior (therapy)