Objective: To explore the value of
albumin-
bilirubin (ALBI) grade combined with serum
ammonia in the diagnosis of
cirrhosis with
hepatic encephalopathy (HE). Methods: The serum level of total
bilirubin(TBIL),
albumin( ALB )and blood
ammonia were detected in 139 patients including 73
cirrhosis patients without HE and 66
cirrhosis patients with HE from January 2015 to January 2017 in Beijing You'an Hospital, and the relationship between ALBI and blood
ammonia value and Child grade and
hepatic encephalopathy was analyzed. Results: The level of ALBI and blood
ammonia were more and more higher with the increase of Child grade, the level of ALBI in Child A, B and C were -2.3±0.6, -1.7±0.5, -0.9±0.4, and there was a statistically significant(F=125.100, P<0.001). The blood
ammonia concentration in Child A, B and C were(42.6±16.0), (56.1±31.2), (69.8±34.7) μmol/L, and there was a statistically significant(F=7.400, P<0.001). The level of ALBI was higher with the increase of model for
end-stage liver disease (MELD) grade, and there was a positive correlation(r=0.547, P<0.001). The ALBI value in the HE group was higher than the
cirrhosis patients without HE((-1.1±0.5)vs(-1.6±0.7)), and the difference was statistically significant (t=5.244, P<0.001). Level of blood
ammonia in the HE group was(83.6±39.5)μmol/L, which was higher than the level of
cirrhosis patients without HE(42.9±17.0)μmol/L, and the difference was statistically significant (t=8.130, P<0.001) . When ALBI and blood
ammonia were combined, the ROC curve area was 0.911, the sensitivity was 93.9%, the specificity was 93.2%. Conclusion: There is a significant diagnosis value and high clinical application when ALBI is combined with blood
ammonia to diagnose HE .