Abstract | PURPOSE: METHODS: A large cohort of 1902 early stage invasive breast cancer patients was used to explore the expression of MSK1. Protein expression was examined using standard immunohistochemistry on tissue microarrays. RESULTS: Low MSK1 protein expression was associated with younger age (P = 0.004), higher tumour grade (P < 0.001), higher Nottingham Prognostic Index scores (P = 0.007), negative ER (P < 0.001) and PR (P < 0.001) status, and with triple-negative (P < 0.001) and basal-like (P < 0.001) phenotypes. Low MSK1 protein expression was significantly associated with shorter time to distant metastasis (P < 0.001), and recurrence (P = 0.013) and early death due to breast cancer (P = 0.01). This association between high MSK1 expression and improved breast cancer-specific survival was observed in the whole cohort (P = 0.009) and in the HER2-negative and non-basal like tumours (P = 0.006 and P = 0.024, respectively). Multivariate analysis including other prognostic variables indicated that MSK1 is not an independent marker of outcome. CONCLUSIONS: High MSK1 is associated with improved breast cancer-specific survival in early stage invasive breast cancer patients, and has additional prognostic value in HER2-negative and non-basal like disease. Although not an independent marker of outcome, we believe such findings and significant associations with well-established negative prognostic factors (age, grade, Nottingham Prognostic Index, hormone receptor status, time to distant metastasis, recurrence and triple-negative/basal-like status) warrant further examination and validation in independent patient cohorts.
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Authors | Xuan Pu, Sarah J Storr, Narmeen S Ahmad, Emad A Rakha, Andrew R Green, Ian O Ellis, Stewart G Martin |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 144
Issue 3
Pg. 509-517
(Mar 2018)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 29327245
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Receptor, ErbB-2
- Ribosomal Protein S6 Kinases, 90-kDa
- mitogen and stress-activated protein kinase 1
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(diagnosis, metabolism, mortality, pathology)
- Cell Nucleus
(metabolism)
- Cohort Studies
- Female
- Humans
- Immunohistochemistry
- Middle Aged
- Prognosis
- Receptor, ErbB-2
(metabolism)
- Ribosomal Protein S6 Kinases, 90-kDa
(metabolism)
- Survival Analysis
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