Abstract | BACKGROUND: METHODS: Case records of patients, admitted with status epilepticus to the pediatric inpatient services of a tertiary care teaching hospital of North India between January 2014 and December 2016 were reviewed. Those with refractory status epilepticus who failed to respond to midaolam infusion and phenobarbitone coma was used were included for analysis. RESULTS: Overall, 108 children presented in status, of which 34 developed refractory status epilepticus. Of these 34, 21 responded to midazolam infusion and in 13 high dose phenobarbitone coma following a standardised protocol was used. Amongst these 13 (8 males and 5 females, median age 6 years, IQR: 2.5-9.5), 12 responded and 1 succumbed. The median time to clinical seizure resolution and desired electroencephalographic changes post phenobarbitone initiation were 16 (IQR: 12-25) and 72 h (IQR: 48-120) respectively. CONCLUSION: High dose phenobarbitone appears to be an effective therapeutic modality in pediatric refractory status epilepticus. The current study provides a protocol for its use which can be validated in future studies with larger sample size.
|
Authors | Sheffali Gulati, Vishal Sondhi, Biswaroop Chakrabarty, Prashant Jauhari, Rakesh Lodha, Jhuma Sankar |
Journal | Brain & development
(Brain Dev)
Vol. 40
Issue 4
Pg. 316-324
(Apr 2018)
ISSN: 1872-7131 [Electronic] Netherlands |
PMID | 29306558
(Publication Type: Journal Article, Review)
|
Copyright | Copyright © 2018 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Anticonvulsants
- Midazolam
- Phenobarbital
|
Topics |
- Adolescent
- Anticonvulsants
(administration & dosage)
- Child
- Child, Preschool
- Clinical Protocols
- Coma
(chemically induced)
- Drug Resistance
- Female
- Humans
- Infant
- Male
- Midazolam
(administration & dosage)
- Phenobarbital
(administration & dosage)
- Retrospective Studies
- Status Epilepticus
(mortality, therapy)
|