Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health.

Abstract

BACKGROUND AND AIMS:

Mild endogenous elevation of unconjugated bilirubin (UCB) as seen in Gilbert's syndrome (GS), might mitigate cardiovascular disease (CVD) risk factors including overweight/obesity. This study aimed to determine whether hyperbilirubinaemia is linked to improved anthropometric data and lipid profile.

METHODS:

Our study considered GS and age-/gender-matched healthy controls (n = 248). Additionally, obese female type 2 diabetic patients (DM2) (n = 26) were included as a "disease control group".

RESULTS:

BMI, hip circumference (HC), and lipid profile were significantly lower in GS. UCB was inversely correlated with BMI (p <0 .001), HC as well as with fat mass (FM) and lipid variables (p < 0.05). Moreover, DM2 patients had significantly lower UCB compared to GS and healthy controls. Older GS subjects (≥35 years) had significantly reduced anthropometric data and improved lipid profile.

CONCLUSIONS:

Our results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia.

• Authors: Nazlisadat Seyed Khoei, Annemarie Grindel, Marlies Wallner, Christine Mölzer, Daniel Doberer, Rodrig Marculescu, Andrew Bulmer, Karl-Heinz Wagner
• Journal: Atherosclerosis (Atherosclerosis) Vol. 269 Pg. 306-311 (02 2018) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 29279144 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Lipids
• Bilirubin

Topics

• Adiposity
• Adult
• Age Factors
• Austria (epidemiology)
• Bilirubin (blood)
• Biomarkers (blood)
• Body Mass Index
• Case-Control Studies
• Diabetes Mellitus, Type 2 (blood, epidemiology)
• Dyslipidemias (blood, diagnosis, epidemiology, prevention & control)
• Female
• Gilbert Disease (blood, diagnosis, epidemiology)
• Health Status
• Humans
• Lipids (blood)
• Male
• Middle Aged
• Obesity (blood, diagnosis, epidemiology, prevention & control)
• Prevalence
• Protective Factors
• Risk Factors
• Up-Regulation
• Weight Gain
• Young Adult