Role of heat shock factor 1 expression in the microenvironment of intrahepatic cholangiocarcinomas.

Abstract

BACKGROUND AND AIM:

Heat shock factor 1 (HSF1), a master regulator of heat shock response, has been shown to play a multifaceted role in cancer progression. However, the clinical significance and biological effect of HSF1 expression in intrahepatic cholangiocarcinoma (IHCC) remain unknown.

METHODS:

Forty-nine patients with IHCC who underwent hepatic resection were enrolled in this study. HSF1 expression in tumor tissue was determined by immunohistochemistry, and patients were divided into two groups, those with high (n = 20) and low (n = 29) HSF1 expression. Clinicopathological factors including prognosis were compared in these two groups.

RESULTS:

HSF1 expression was significantly higher in tumors than in normal tissue. The overall survival rate was significantly lower in patients with high than low HSF1. Multivariate analysis showed that high HSF1 expression was a factor independently prognostic of patient survival.

CONCLUSION:

High HSF1 expression in tumor tissues may be a prognostic biomarker in patients with IHCC.

• Authors: Yoichiro Kawashita, Yuji Morine, Yu Saito, Chie Takasu, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, Masato Yoshikawa, Satoru Imura, Toshiyuki Yagi, Mitsuo Shimada
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 33 Issue 7 Pg. 1407-1412 (Jul 2018) ISSN: 1440-1746 [Electronic] Australia
• PMID: 29278438 (Publication Type: Journal Article)
• Copyright: © 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

Chemical References

• HSF1 protein, human
• Heat Shock Transcription Factors

Topics

• Adult
• Aged
• Aged, 80 and over
• Bile Duct Neoplasms (genetics, metabolism, mortality, pathology)
• Cell Line, Tumor
• Cholangiocarcinoma (genetics, metabolism, mortality, pathology)
• Disease Progression
• Female
• Gene Expression (genetics)
• Heat Shock Transcription Factors (genetics, metabolism, physiology)
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Multivariate Analysis
• Prognosis
• Survival Rate
• Tumor Microenvironment (genetics)