HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D.

Abstract

Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

• Authors: Meredith S Shiels, Gregory D Kirk, M Bradley Drummond, Dilsher Dhillon, Samir M Hanash, Ayumu Taguchi, Eric A Engels
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 217 Issue 3 Pg. 413-417 (01 17 2018) ISSN: 1537-6613 [Electronic] United States
• PMID: 29272472 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Chemical References

• Protein Precursors
• Pulmonary Surfactant-Associated Protein D
• Pulmonary Surfactant-Associated Proteins
• RNA, Viral
• SFTPB protein, human

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Cohort Studies
• Female
• HIV (isolation & purification)
• HIV Infections (pathology)
• Humans
• Male
• Middle Aged
• Protein Precursors (blood)
• Pulmonary Surfactant-Associated Protein D (blood)
• Pulmonary Surfactant-Associated Proteins (blood)
• RNA, Viral (blood)
• Surveys and Questionnaires
• Viral Load
• Young Adult