Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release.

Abstract

To improve the efficacy of anti-inflammatory factors in patients who undergo cataract surgery, poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) hydrogels containing β-cyclodextrin (β-CD) (pHEMA/MMA/β-CD) were designed and prepared as intraocular lens (IOLs) biomaterials that could be loaded with and achieve the sustained release of dexamethasone. A series of pHEMA/MMA/β-CD copolymers containing different ratios of β-CD (range, 2.77 to 10.24 wt.%) were obtained using thermal polymerization. The polymers had high transmittance at visible wavelengths and good biocompatibility with mouse connective tissue fibroblasts. Drug loading and release studies demonstrated that introducing β-CD into hydrogels increased loading efficiency and achieved the sustained release of the drug. Administering β-CD via hydrogels increased the equilibrium swelling ratio, elastic modulus and tensile strength. In addition, β-CD increased the hydrophilicity of the hydrogels, resulting in a lower water contact angle and higher cellular adhesion to the hydrogels. In summary, pHEMA/MMA/β-CD hydrogels show great potential as IOL biomaterials that are capable of maintaining the sustained release of anti-inflammatory drugs after cataract surgery.

• Authors: Xiao Li, Yang Zhao, Kaijie Wang, Lei Wang, Xiaohui Yang, Siquan Zhu
• Journal: PloS one (PLoS One) Vol. 12 Issue 12 Pg. e0189778 ( 2017) ISSN: 1932-6203 [Electronic] United States
• PMID: 29244868 (Publication Type: Journal Article)

Chemical References

• Biocompatible Materials
• Cyclodextrins
• Hydrogels
• Methylmethacrylates
• Polymers
• Polyhydroxyethyl Methacrylate
• HTR composite
• Dexamethasone

Topics

• Animals
• Biocompatible Materials (chemistry, therapeutic use)
• Cataract (drug therapy, pathology)
• Cataract Extraction
• Cell Line
• Cyclodextrins (chemistry, therapeutic use)
• Dexamethasone (chemistry, therapeutic use)
• Drug Liberation
• Eye (cytology, drug effects)
• Humans
• Hydrogels (chemistry, therapeutic use)
• Lenses, Intraocular
• Methylmethacrylates (chemistry, therapeutic use)
• Mice
• Polyhydroxyethyl Methacrylate (chemistry, therapeutic use)
• Polymers (chemistry, therapeutic use)