Dengue fever: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine.

Abstract

Dengue is an arbovirus affecting humans and spread by mosquitoes. Severe dengue follows a secondary infection with a different virus serotype. The problem is truly global as it is endemic in over 100 countries. Severe dengue can be a life-threatening because of increased vascular permeability, resulting in leakage of fluid from the intravascular compartment to the extravascular space. When major bleeding does occur, it is almost invariably combined with profound shock since this, in combination with thrombocytopenia, hypoxia, and acidosis, can lead to multiple organ failure and disseminated intravascular coagulation. Dengue hemorrhagic fever and dengue shock syndrome are among the leading causes of morbidity and mortality in patients suffering from Dengue. Commercial rapid tests and ELISA kits are freely available, ensuring early diagnosis. The basis of management of severe dengue is effective fluid replacement. Future directions in management will involve vector control and development of effective vaccination.

• Authors: Pravin Amin, Özlem Acicbe, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Tim Baker, Guy A Richards
• Journal: Journal of critical care (J Crit Care) Vol. 43 Pg. 346-351 (Feb 2018) ISSN: 1557-8615 [Electronic] United States
• PMID: 29221616 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Dengue Vaccines

Topics

• Advisory Committees
• Community Health Services
• Critical Care
• Dengue (diagnosis, prevention & control, therapy)
• Dengue Vaccines
• Developing Countries
• Diagnostic Tests, Routine
• Early Diagnosis
• Health Resources
• Humans
• Practice Guidelines as Topic
• Risk Factors
• Societies, Medical
• Tropical Medicine