Recently, several studies have reported that the expression of
cyclin B1 may be associated with the prognosis of
cancer. Nevertheless, their conclusions were still controversial. The present was designed to analyze and evaluate the prognostic role of
cyclin B1 expression in patients with digestive
cancer. PubMed, Embase, Cochrane Library and Web of Science were searched to January, 2017. Pooled odds ratio (OR) with 95% confidence intervals (CIs) were estimated. For the pooled OR estimates of OS, we performed subgroup analysis. Besides, sensitivity analysis was performed to examine the stability of the combined results. All statistical analyses were performed using standard statistical procedures provided in RevMan 5.2. A total of 12 studies (N = 2080 participants) were included for this meta-analysis. The positive/high expression of
cyclin B1 had an obvious association with both 3-year overall survival (OR 0.21, 95% CI 0.12-0.37; P < 0.00001) and 5-year overall survival (OR 0.20, 95% CI 0.12-0.34; P < 0.00001) in
esophageal cancer, and 5-year overall survival of
colorectal cancer (OR 2.01, 95% CI 1.32-3.08; P = 0.001). This meta-analysis indicated that positive/high expression of
cyclin B1 may have a close association with worse survival in patients with
esophageal cancer, but better prognosis in patients with
colorectal cancer.