Centiloid method evaluation for amyloid PET of subcortical vascular dementia.

Abstract

Reference region selection is important for proper amyloid PET analysis, especially in subcortical vascular dementia (SVaD) patients. We investigated reference region differences between SVaD and Alzheimer's disease (AD) using Centiloid scores. In 57 [C-11] Pittsburgh compound B (PiB) positive (+) AD and 23 PiB (+) SVaD patients, we assessed standardized PiB uptake and Centiloid scores in disease-specific cortical regions, with several reference regions: cerebellar gray (CG), whole cerebellum (WC), WC with brainstem (WC + B), pons, and white matter (WM). We calculated disease group differences from young controls (YC) and YC variance according to reference region. SVaD patients showed large effect sizes (Cohen's d > 0.8) using all reference regions. WM and pons showed larger YC variances than other regions. Findings were similar for AD patients. CG, WC, and WC + B, but not WM or pons, are reliable reference regions for amyloid imaging analysis in SVaD.

• Authors: Hyuk Jin Yun, Seung Hwan Moon, Hee Jin Kim, Samuel N Lockhart, Yearn Seong Choe, Kyung Han Lee, Duk L Na, Jong-Min Lee, Sang Won Seo
• Journal: Scientific reports (Sci Rep) Vol. 7 Issue 1 Pg. 16322 (11 24 2017) ISSN: 2045-2322 [Electronic] England
• PMID: 29176753 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid

Topics

• Amyloid (metabolism)
• Brain Stem (diagnostic imaging)
• Cerebellum (diagnostic imaging)
• Dementia, Vascular (diagnostic imaging)
• Positron-Emission Tomography (methods)
• White Matter (diagnostic imaging)