Abstract | PURPOSE:
Epilepsy is one of the most common primary brain disorders. Nonparaneoplastic autoimmune encephalitis is increasingly recognized as an important cause of adult onset epilepsy. However, only in rare cases an initiating factor of the syndrome can be identified. Autoantibody detection after central nervous herpesvirus infection indicates a postviral etiology in a subgroup of patients. In order to analyze a possible underrecognition of postinfectious autoimmunity we performed a large-scale analysis of herpesvirus DNA in cerebrospinal fluid samples from patients with clinical signs of autoimmune encephalitis. METHODS: Real time PCR for HSV 1/2, CMV, EBV, VZV, HHV-6A, HHV-6B, HHV-7 and HHV-8 was performed in cerebrospinal fluid samples from 113 patients with epilepsy and suspected autoimmune encephalitis. Indirect immunofluorescence analysis was used for autoantibody analysis. RESULTS: CONCLUSION:
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Authors | Freya Poulheim, Laura Esposito, Christian E Elger, Anna M Eis-Hübinger, Albert J Becker, Pitt Niehusmann |
Journal | Seizure
(Seizure)
Vol. 53
Pg. 100-102
(Dec 2017)
ISSN: 1532-2688 [Electronic] England |
PMID | 29156319
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Autoantibodies
- DNA, Viral
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Topics |
- Adult
- Autoantibodies
(cerebrospinal fluid)
- Autoimmune Diseases of the Nervous System
(cerebrospinal fluid)
- DNA, Viral
(cerebrospinal fluid)
- Encephalitis
(cerebrospinal fluid)
- Epilepsy
(cerebrospinal fluid)
- Female
- Herpesviridae
- Herpesviridae Infections
(cerebrospinal fluid)
- Humans
- Male
- Middle Aged
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