The current European Society of Cardiology (ESC) guidelines on
peripheral arterial diseases include recommendations on diagnostics and treatment of atherosclerotic manifestations in peripheral arteries. Because of the high coincidence of
atherosclerosis in different arterial territories, screening for other atherosclerotic lesions is necessary in patients with clinical symptoms in one vascular bed. Consistent treatment of cardiovascular risk factors is important in all patients with peripheral
atherosclerosis. This includes smoking cessation,
statin therapy and control of blood pressure and
blood glucose. All patients with
carotid artery stenosis should be treated with
antiplatelet drugs. In patients with symptomatic
carotid artery stenosis and low periprocedural risk, early revascularization is recommended when the degree of
stenosis is more than 50%. In asymptomatic
carotid artery stenosis revascularization should only be considered if the risk for cerebral embolization is high and the periprocedural risk is low. Patients with
peripheral arterial occlusive disease should only be treated with an
antiplatelet drug if they are symptomatic. In cases of
intermittent claudication supervised exercise training is strongly recommended. When activities of daily life are compromised despite training, revascularization by endovascular
therapy first should be considered. In
chronic limb-threatening ischemia early revascularization should be considered, preferably by venous bypass surgery. In patients with arterial
hypertension and specific risk factors screening for
renal artery stenosis is recommended. Particularly in patients with atherosclerotic
renal artery stenosis, the indications for revascularization should be assessed very carefully.