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Bilateral Candida endophthalmitis accompanying Candida lusitaniae bloodstream infection: A case report.

Abstract
Candida lusitaniae is an uncommon cause of candidiasis in humans. Ocular manifestations of C. lusitaniae infection have not been reported. C. lusitaniae is either intrinsically resistant to amphotericin B or can acquire such resistance. We describe a case of bilateral endophthalmitis due to C. lusitaniae bloodstream infection in a liver transplant patient with rectal cancer. The patient suffered fungemia and endophthalmitis and was treated with liposomal amphotericin B. The isolate was identified as C. lusitaniae by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, the system based on biochemical tests, and sequencing of the internal transcribed spacer region. The minimal inhibitory concentrations were 0.06 μg/mL for amphotericin B and 2.0 μg/mL for fluconazole. Repeat blood cultures were negative and the endophthalmitis improved following treatment with liposomal amphotericin B. However, the treatment was changed to fluconazole due to nephrotoxicity. No recurrence occurred after completion of treatment.
AuthorsShinya Yamamoto, Mahoko Ikeda, Fumie Fujimoto, Koh Okamoto, Yoshitaka Wakabayashi, Tomoaki Sato, Keita Tatsuno, Toshikatsu Kaburaki, Shuntaro Yoshida, Shu Okugawa, Kazuhiko Koike, Kyoji Moriya
JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 24 Issue 2 Pg. 147-149 (Feb 2018) ISSN: 1437-7780 [Electronic] Netherlands
PMID29102349 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Antifungal Agents
  • liposomal amphotericin B
  • Amphotericin B
  • Fluconazole
Topics
  • Aged
  • Amphotericin B (therapeutic use)
  • Antibiotic Prophylaxis
  • Antifungal Agents (therapeutic use)
  • Candida (drug effects, isolation & purification)
  • Candidemia (diagnosis, drug therapy)
  • Candidiasis (complications, diagnosis, drug therapy)
  • Catheter-Related Infections (diagnosis, drug therapy)
  • Endophthalmitis (diagnosis, drug therapy, microbiology)
  • Eye Infections, Fungal (diagnosis, microbiology)
  • Fluconazole (therapeutic use)
  • Humans
  • Liver Transplantation
  • Male
  • Microbial Sensitivity Tests
  • Rectal Neoplasms (complications)
  • Risk Factors

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