LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.

Abstract	Long noncoding RNAs (lncRNAs) are RNA molecules more than 200 nucleotides in length that do not encode proteins. Recent studies have reported increasing numbers of functional lncRNAs. Maternally expressed gene 3 (MEG3) is a maternally imprinted gene encoding an lncRNA that plays a tumor suppressor role in various tumors. However, there has been rare report on mechanism of tumorigenesis and progression of endometrial carcinoma. In the present study, we found significantly lower MEG3 expression in endometrial carcinoma tissues than in normal endometrial tissues. MEG3 overexpression inhibited endometrial cancer cell proliferation, invasion, and metastasis; promoted apoptosis; and inhibited the activation of the phosphoinositide 3-kinase (PI3K)/m-TOR signaling pathway. RNA immunoprecipitation assay (RIP) showed that MEG3 can combine directly with PI3K. Tumor xenograft implantation in nude mice showed that MEG3 could significantly suppress tumor growth. These findings provide potential new therapeutic targets for treating endometrial cancer.
Authors	Kai-Xuan Sun, Dan-Dan Wu, Shuo Chen, Yang Zhao, Zhi-Hong Zong
Journal	Apoptosis : an international journal on programmed cell death (Apoptosis) Vol. 22 Issue 12 Pg. 1543-1552 (Dec 2017) ISSN: 1573-675X [Electronic] Netherlands
PMID	29094270 (Publication Type: Journal Article)
Chemical References	MEG3 non-coding RNA, human RNA, Long Noncoding mTOR protein, mouse TOR Serine-Threonine Kinases
Topics	Animals Apoptosis (genetics) Carcinogenesis (genetics) Cell Line, Tumor Cell Movement (genetics) Cell Proliferation (genetics) Cell Transformation, Neoplastic (genetics) Disease Progression Endometrial Neoplasms (genetics, metabolism, physiopathology) Female Gene Expression Gene Expression Regulation, Neoplastic Humans Mice Mice, Nude Phosphatidylinositol 3-Kinases (genetics, metabolism) RNA, Long Noncoding (genetics, metabolism) Signal Transduction TOR Serine-Threonine Kinases (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!