Abstract |
Resident adrenal mast cells have been shown to activate aldosterone secretion in rat and man. Especially, mast cell proliferation has been observed in adrenal tissues from patients with aldosterone-producing adrenocortical adenoma. In the present study, we show that the activity of adrenal mast cells is stimulated by low-sodium diet and correlates with aldosterone synthesis in C57BL/6 and BALB/c mice. We have also investigated the regulation of aldosterone secretion in mast cell-deficient C57BL/6 KitW-sh/W-sh mice in comparison with wild-type C57BL/6 mice. KitW-sh/W-sh mice submitted to normal sodium diet had basal plasma aldosterone levels similar to those observed in wild-type animals. Conversely, low-sodium diet unexpectedly induced an exaggerated aldosterone response, which seemed to result from an increase in adrenal renin and angiotensin type 1 receptor expression. Severe hyperaldosteronism was associated with an increase in systolic blood pressure and marked hypokalemia, which favored polyuria. Adrenal renin and angiotensin type 1 receptor overexpression may represent a compensatory mechanism aimed at activating aldosterone production in the absence of mast cells. Finally, C57BL/6 KitW-sh/W-sh mice represent an unexpected animal model of primary aldosteronism, which has the particularity to be triggered by sodium restriction.
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Authors | Hadrien-Gaël Boyer, Julien Wils, Sylvie Renouf, Arnaud Arabo, Céline Duparc, Isabelle Boutelet, Hervé Lefebvre, Estelle Louiset |
Journal | Hypertension (Dallas, Tex. : 1979)
(Hypertension)
Vol. 70
Issue 6
Pg. 1256-1263
(12 2017)
ISSN: 1524-4563 [Electronic] United States |
PMID | 29084882
(Publication Type: Journal Article)
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Copyright | © 2017 American Heart Association, Inc. |
Chemical References |
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Topics |
- Adrenal Cortex Neoplasms
(metabolism, pathology)
- Adrenocortical Adenoma
(metabolism, pathology)
- Aldosterone
(metabolism)
- Animals
- Diet, Sodium-Restricted
- Female
- Hyperaldosteronism
(etiology, metabolism, pathology)
- Male
- Mast Cells
(metabolism)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Neoplasms, Experimental
- Renin
(metabolism)
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