Investigation on effect of basalin coated silver nanoparticles as antioxidant for alleviating peripheral neuropathy in mice treated with oxaliplatin.

Abstract

A facile, convenient, and green method for the synthesis of BAgNPs by using basalin is proposed in this work. The capping of the basalin on the surface of BAgNP was confirmed by the zeta potential and FTIR findings. Further, we have injected prepared BAgNPs into oxaliplatin-treated mice to alleviate neuropathic pain. The aluminum levels in the DRG were reduced by the chelating activity of BAgNPs. Moreover, behavioral analyses also manifested that the accumulation of aluminum on the DRG might be a reason for neuropathic hyperalgesia. These findings also recommended that the chelation of aluminum by AgNPs could provide an effective remedy to alleviate the symptoms of oxaliplatin-induced neuropathic pain in cancer patients.

• Authors: Lei Gao, Yumei Zheng, Chengbo Zhao, Hongtao Teng
• Journal: Journal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 177 Pg. 56-61 (Dec 2017) ISSN: 1873-2682 [Electronic] Switzerland
• PMID: 29069632 (Publication Type: Journal Article)
• Copyright: Copyright © 2017. Published by Elsevier B.V.

Chemical References

• Aniline Compounds
• Antioxidants
• Organoplatinum Compounds
• TRPA1 Cation Channel
• Trpa1 protein, mouse
• Oxaliplatin
• Silver
• Platinum
• fluchloralin
• Aluminum

Topics

• Aluminum (metabolism)
• Aniline Compounds (chemistry)
• Animals
• Antioxidants (chemical synthesis, chemistry, therapeutic use)
• Apoptosis (drug effects)
• Brain (metabolism, pathology)
• Metal Nanoparticles (chemistry)
• Mice
• Organoplatinum Compounds (toxicity)
• Oxaliplatin
• Peripheral Nervous System Diseases (chemically induced, pathology, prevention & control)
• Platinum (metabolism)
• Silver (chemistry)
• Spectroscopy, Fourier Transform Infrared
• TRPA1 Cation Channel (genetics, metabolism)