Abstract | Background:
Isoflurane preconditioning (IPC) induces cerebral ischaemic tolerance, but the mechanism remains poorly understood. The aim of this study was to determine changes in mitochondrial function in the brain after IPC, and whether the cannabinoid receptor 1 (CB1R) could be involved in the mechanism of mitochondrial protection mediated by IPC. Methods: Results: Conclusions: Our results indicate that IPC elicits brain ischaemic tolerance and mitochondrial protection by activating the CB1R, which provides a new mechanism for IPC-induced neuroprotection against cerebral ischaemia.
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Authors | M Cai, Q Yang, G Li, S Sun, Y Chen, L Tian, H Dong |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 119
Issue 6
Pg. 1213-1223
(Dec 01 2017)
ISSN: 1471-6771 [Electronic] England |
PMID | 29045576
(Publication Type: Journal Article)
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Copyright | © The Author 2017. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: [email protected] |
Chemical References |
- Anesthetics, Inhalation
- Cnr1 protein, rat
- Neuroprotective Agents
- Receptor, Cannabinoid, CB1
- Isoflurane
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Topics |
- Anesthetics, Inhalation
(pharmacology)
- Animals
- Brain Ischemia
(genetics, prevention & control)
- Disease Models, Animal
- Infarction, Middle Cerebral Artery
(genetics, prevention & control)
- Ischemic Preconditioning
(methods)
- Isoflurane
(pharmacology)
- Male
- Mitochondria
(genetics, physiology)
- Neuroprotective Agents
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptor, Cannabinoid, CB1
(genetics, metabolism)
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