Abstract | BACKGROUND: It has been difficult to determine the individual impact of prenatal and postnatal tobacco smoke exposure (TSE) on childhood lung function, as children are often exposed to both. OBJECTIVE: The goal of this study was to determine the association between current TSE and airflow obstruction while adjusting for self-reported prenatal TSE. METHODS: Children aged 6 to 11 years who participated in the National Health and Nutrition Examination Survey (2007-2012) who had serum cotinine levels measured and spirometry performed were included. Logistic regression was used to determine the association between log-transformed serum cotinine level and airflow obstruction while adjusting for confounders; the analysis was then stratified according to asthma status. The final model included both log-transformed serum cotinine level and prenatal exposure as covariates. RESULTS: The sample consisted of 2,070 children; 9.6% had airflow obstruction. The association between cotinine levels and airflow obstruction was significant in an unadjusted analysis (OR, 1.12 [95% CI, 1.02-1.23]). In the multivariate analysis with both exposures included as covariates, serum cotinine level was not significantly associated with airflow obstruction (ORadj, 1.07 [95% CI, 0.94-1.21]), and no association was seen in children with asthma and nonasthmatic children. Prenatal smoking was associated with airflow obstruction in children with asthma (ORadj, 2.51 [95% CI, 1.08-5.79]) but not in nonasthmatic children (ORadj, 1.08 [95% CI, 0.53-2.18]). CONCLUSIONS: Current TSE was not independently associated with airflow obstruction in school-aged children. Prenatal TSE was associated with airflow obstruction in children with asthma. Repeated studies into potential mediators and confounders of this relationship are needed.
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Authors | Stacey-Ann Whittaker Brown, Bian Liu, Emanuela Taioli |
Journal | Chest
(Chest)
Vol. 153
Issue 3
Pg. 630-637
(03 2018)
ISSN: 1931-3543 [Electronic] United States |
PMID | 29037529
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Tobacco Smoke Pollution
- Cotinine
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Topics |
- Airway Obstruction
(epidemiology)
- Asthma
(epidemiology)
- Biomarkers
(blood)
- Child
- Cotinine
(blood)
- Female
- Humans
- Male
- Nutrition Surveys
- Spirometry
- Tobacco Smoke Pollution
(statistics & numerical data)
- United States
(epidemiology)
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