ERRATUM.

Abstract

Histone deacetylase (HDAC) inhibitors have been shown to enhance the effects of 5-fluorouracil (5-FU) against various cancer cells; however, no report has shown that an HDAC inhibitor may enhance the effects of 5-FU with radiation. Therefore, we investigated whether the novel HDAC inhibitor OBP-801/YM753 could enhance the effects of 5-FU with radiation on esophageal squamous carcinoma KYSE170 cells. The inhibition of the cell growth was significantly stronger with the combination of OBP-801/YM753 with 5-FU than with the 5-FU treatment only. Furthermore, inhibition of the colony formation was the most effective with the combined treatment of OBP-801/YM753, 5-FU, and radiation. Western blot analysis showed that OBP-801/YM753 suppressed the expression of thymidylate synthase induced by 5-FU. Therefore, this three-combined therapy is promising for patients with esophageal squamous carcinoma.

• Authors: Akinobu Furutani, Yoshihiro Sowa, Hitoshi Fujiwara, Eigo Otsuji, Toshiyuki Sakai
• Journal: Oncology research (Oncol Res) Vol. 23 Issue 1 Pg. 87 (Jan 21 2016) ISSN: 1555-3906 [Electronic] United States
• PMID: 29021025 (Publication Type: Journal Article)