Facile Coordination-Precipitation Route to Insoluble Metal Roussin's Black Salts for NIR-Responsive Release of NO for Anti-Metastasis.

Abstract

A facile and general coordination-precipitation method is developed to synthesize insoluble metal Roussin's black salts (Me-RBSs) as a new type of NIR-responsive NORMs. The weak-field ligand coordination of metal+-RBS- brings a NIR absorption effect of Me-RBSs, and further gives rise to the NIR adsorption-dependent NIR-responsive NO release profile. Intratumoral NIR-responsive release of NO effectively inhibits the growth and metastasis of the metastatic breast cancer. Aqueous insolubility of Me-RBSs ensures lower cytotoxicity and higher thermostability compared with traditional soluble RBSs. This work establishes a new class of NIR-sensitive NO donors, and may spark new inspiration for designing intelligent gas-releasing molecules.

• Authors: Lijuan Chen, Qianjun He, Minyi Lei, Liwei Xiong, Kun Shi, Liwei Tan, Zhaokui Jin, Tianfu Wang, Zhiyong Qian
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 9 Issue 42 Pg. 36473-36477 (Oct 25 2017) ISSN: 1944-8252 [Electronic] United States
• PMID: 28994571 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Iron Compounds
• Metals
• Nitroso Compounds
• Salts
• Nitric Oxide
• Roussin's Black Salt

Topics

• Antineoplastic Agents
• Drug Delivery Systems
• Humans
• Infrared Rays
• Iron Compounds (chemistry)
• Metals
• Neoplasms
• Nitric Oxide
• Nitroso Compounds (chemistry)
• Salts