Mepolizumab-a novel option for the treatment of hypereosinophilic syndrome in childhood.

Abstract

BACKGROUND:

Mepolizumab was originally intended as a therapeutic agent for atopic asthma in adults, and consequently, little is known about its use in children. Up to now, corticosteroids have formed the basis of the initial treatment of hypereosinophilic syndromes and are shown to be effective in most patients. To analyze the effect of mepolizumab in children is the aim of this study.

METHODS:

We are reporting the experience of the effect of mepolizumab in 2 pediatric patients with hypereosinophilic syndrome that was not sufficiently controlled by other drugs. In addition, the literature regarding the treatment with mepolizumab in pediatric and adult patients is reviewed for the most important studies regarding safety and efficacy.

RESULTS:

Mepolizumab therapy showed in 2 pediatric patients with severe hypereosinophilic syndrome a safe and efficient therapeutic approach. No significant intolerances appeared. Furthermore, treatment with systemic corticosteroids was terminated, and therefore, severe side effects were avoided in our pediatric cases.

CONCLUSIONS:

Anti-IL-5 antibodies, which can be applied without substantial drug intolerances, are a new, safe, and effective treatment option for pediatric patients with hypereosinophilic syndrome.

• Authors: Carsten Schwarz, Thilo Müller, Susanne Lau, Kirn Parasher, Doris Staab, Ulrich Wahn
• Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (Pediatr Allergy Immunol) Vol. 29 Issue 1 Pg. 28-33 (02 2018) ISSN: 1399-3038 [Electronic] England
• PMID: 28986919 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Chemical References

• Antibodies, Monoclonal, Humanized
• Interleukin-5
• mepolizumab

Topics

• Adolescent
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Bronchoscopy (methods)
• Child
• Female
• Humans
• Hypereosinophilic Syndrome (diagnosis, drug therapy)
• Interleukin-5 (antagonists & inhibitors)
• Leukocyte Count (methods)
• Male
• Tomography, X-Ray Computed (methods)
• Treatment Outcome