Effect of restricted protein diet supplemented with keto analogues in end-stage renal disease: a systematic review and meta-analysis.

Abstract

AIM:

To evaluate the efficacy and safety of the restricted protein diet supplemented with keto analogues when applied in end-stage renal disease (ESRD).

METHODS:

The Cochrane Library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to January 2017. Clinical trials were analyzed using RevMan 5.3 software.

RESULTS:

Five randomized controlled trials were selected and included in this study according to our inclusion and exclusion criteria. Changes in serum albumin, PTH, triglyceride, cholesterol, calcium, phosphorus, hemoglobin, Kt/v and CRP before and after treatment were analyzed. Meta-analysis results indicated that, compared with normal protein diet, low-protein diet (LPD) supplemented with keto analogues (sLPD) could improve serum albumin (P < 0.00001), hyperparathyroidism (P < 0.00001) and hyperphosphatemia (P = 0.008). No differences in triglyceride, cholesterol, hemoglobin, Kt/v and CRP were observed between different protein intake groups.

CONCLUSION:

Restricted protein diet supplemented with keto analogues (sLPD) may improve nutritional status and prevent hyperparathyroidism in ESRD patients. The current data were mainly obtained from short-term, single-center trails with small sample sizes and limited nutritional status indexes, indicating a need for further study.

• Authors: Zheng Jiang, Yi Tang, Lichuan Yang, Xuhua Mi, Wei Qin
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 50 Issue 4 Pg. 687-694 (Apr 2018) ISSN: 1573-2584 [Electronic] Netherlands
• PMID: 28975468 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Chemical References

• Keto Acids
• Serum Albumin

Topics

• Diet, Protein-Restricted (adverse effects)
• Dietary Supplements
• Humans
• Hyperparathyroidism (therapy)
• Hyperphosphatemia (therapy)
• Keto Acids (therapeutic use)
• Kidney Failure, Chronic (diet therapy, drug therapy)
• Nutritional Status
• Randomized Controlled Trials as Topic
• Serum Albumin (metabolism)