Abstract | Background: Enterovirus D68 (EV-D68)-associated acute flaccid myelitis (AFM) is a devastating neurological disease for which there are no treatments of proven efficacy. The unpredictable temporal and geographic distribution of cases and the rarity of the disease make it unlikely that data from randomized controlled trials will be available to guide therapeutic decisions. We evaluated the following 3 widely used empirical therapies for the ability to reduce the severity of paralysis in a mouse model of EV-D68 infection: (1) human intravenous immunoglobulin ( hIVIG), (2) fluoxetine, and (3) dexamethasone. Methods: Neonatal mice were injected intramuscularly with a human 2014 EV-D68 isolate that reliably induces paralysis in mice due to infection and loss of spinal cord motor neurons. Mice receiving treatments were evaluated for motor impairment, mortality, and spinal cord viral load. Results: Conclusion: Results in this model of EV-D68-associated AFM provide a rational basis for selecting empirical therapy in humans and establish this model as a useful system for evaluating other potential therapies.
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Authors | Alison M Hixon, Penny Clarke, Kenneth L Tyler |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 216
Issue 10
Pg. 1245-1253
(12 05 2017)
ISSN: 1537-6613 [Electronic] United States |
PMID | 28968718
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected]. |
Chemical References |
- Antibodies, Neutralizing
- Antibodies, Viral
- Immunoglobulins, Intravenous
- Serotonin Uptake Inhibitors
- Fluoxetine
- Dexamethasone
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Topics |
- Animals
- Antibodies, Neutralizing
(blood, immunology)
- Antibodies, Viral
(blood, immunology)
- Dexamethasone
(administration & dosage)
- Disease Models, Animal
- Enterovirus D, Human
(immunology)
- Fluoxetine
(administration & dosage)
- Immunoglobulins, Intravenous
(administration & dosage)
- Mice
- Myelitis
(diagnosis, physiopathology, therapy, virology)
- Neutralization Tests
- Paralysis
(diagnosis, physiopathology, therapy, virology)
- Selective Serotonin Reuptake Inhibitors
(administration & dosage)
- Treatment Outcome
- Viral Load
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