The
mitogen-activated protein kinases (MAPKs) are fundamental in
inflammation and
cancer control, through the crosstalk between the redox regulated
nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kB (NFκB) gene expression. MAPKs regulate various cellular activities involved in
cancer progression, including proliferation, apoptosis and immune escape and blockade of upstream
kinases is a current therapeutic strategy. However, these
therapies are associated with some adverse effects and with the paradoxical activation of the MAPKs pathway. In the context of
cancer prevention and treatment, it has been suggested that dietary factors are able to modulate
cancer initiation and progression by interacting with the MAPKs. Within these dietary factors, virgin
olive oil (VOO) is of particular interest due to its content in
squalene, already used as drug delivery system in
cancer therapy. The aim of this review is to discuss the studies pointing to the effects of olive-derived foodstuff and nutraceuticals on MAPKs signalling cascades. The reviewed experimental studies suggest that the stress-activated JNK and p38 MAPKs could be targets of olive-derived nutraceuticals. The latter, including
phytochemicals from olive cultivation and processing wastes, could be adjuvants in
chemotherapies, whereas VOO could be considered a "natural delivery system" of bioactive
phytochemicals due to its high content in
squalene.