Identification of lncRNA EGOT as a tumor suppressor in renal cell carcinoma.

Abstract

Renal cell carcinoma (RCC) is the most common type of kidney cancer and the prognosis of metastatic RCC remains poor, with a high rate of recurrence and mortality. Long non‑coding RNA (lncRNA) is a class of RNA which serves important roles in multiple cellular processes and tumorigenesis. In the present study, the expression and function of lncRNA eosinophil granule ontogeny transcript (EGOT) were examined in RCC. In 24 paired tissues (RCC tissues and adjacent normal tissues) the results of reverse transcription‑quantitative polymerase chain reaction analysis revealed that EGOT was downregulated in 22 RCC tissues compared with paired tissues. Upregulation of lncRNA EGOT by transfection of 786‑O and ACHN RCC cells with pcDNA3.1‑EGOT suppressed cell proliferation, migration and invasion, and induced RCC cell apoptosis. The results demonstrated that EGOT may serve as a tumor suppressor in RCC and may be a potential prognostic biomarker of RCC.

• Authors: Lu Jin, Jing Quan, Xiang Pan, Tao He, Jia Hu, Yifan Li, Yaoting Gui, Shangqi Yang, Xiangming Mao, Yun Chen, Yongqing Lai
• Journal: Molecular medicine reports (Mol Med Rep) Vol. 16 Issue 5 Pg. 7072-7079 (Nov 2017) ISSN: 1791-3004 [Electronic] Greece
• PMID: 28901455 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• EGOT lncRNA, human
• MicroRNAs
• RNA, Long Noncoding

Topics

• Adult
• Aged
• Apoptosis
• Base Sequence
• Biomarkers, Tumor (genetics, metabolism)
• Carcinoma, Renal Cell (genetics, metabolism, pathology)
• Cell Line, Tumor
• Cell Movement
• Cell Proliferation
• Female
• Humans
• Kidney Neoplasms (genetics, metabolism, pathology)
• Male
• MicroRNAs (chemistry, metabolism)
• Middle Aged
• RNA, Long Noncoding (chemistry, genetics, metabolism)
• Sequence Alignment
• Up-Regulation