Abstract | OBJECTIVE: Although it has been shown that prophylactic vaccination can induce genital immunity, there is inadequate information on human papillomavirus (HPV) vaccine-induced oral immunity, which is of particular interest due to HPV-associated oropharyngeal malignancies and recurrent respiratory papillomatosis. Therefore, we assessed the efficacy of various HPV vaccines against oral HPV pseudovirus (PsV) infection in mice. STUDY DESIGN: Preclinical scientific investigation. METHODS: RESULTS: CONCLUSION: Oral HPV16 PsV infection in mice was completely prevented with all methods of prophylactic HPV immunization. These findings provide preliminary evidence that human vaccines induce protection against oral HPV infection, which has significant public health implications for HPV-associated oropharyngeal malignancies. LEVEL OF EVIDENCE:
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Authors | Julie Ahn, Shiwen Peng, Chien-Fu Hung, Richard B S Roden, Simon R Best |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 128
Issue 1
Pg. E16-E20
(01 2018)
ISSN: 1531-4995 [Electronic] United States |
PMID | 28868617
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Copyright | © 2017 The American Laryngological, Rhinological and Otological Society, Inc. |
Chemical References |
- Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
- Papillomavirus Vaccines
- Luciferases
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Topics |
- Animals
- Female
- Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
(administration & dosage, immunology)
- Humans
- Injections, Intramuscular
- Injections, Subcutaneous
- Luciferases
(metabolism)
- Mice
- Mice, Inbred C57BL
- Oropharyngeal Neoplasms
(immunology, prevention & control, virology)
- Papillomavirus Infections
(immunology, prevention & control, virology)
- Papillomavirus Vaccines
(administration & dosage, immunology)
- Respiratory Tract Infections
(immunology, prevention & control, virology)
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