Circulating resistin levels and risk of multiple myeloma in three prospective cohorts.

Abstract

BACKGROUND:

Resistin is a polypeptide hormone secreted by adipose tissue. A prior hospital-based case-control study reported serum resistin levels to be inversely associated with risk of multiple myeloma (MM). To date, this association has not been investigated prospectively.

METHODS:

We measured resistin concentrations for pre-diagnosis peripheral blood samples from 178 MM cases and 358 individually matched controls from three cohorts participating in the MM cohort consortium.

RESULTS:

In overall analyses, higher resistin levels were weakly associated with reduced MM risk. For men, we observed a statistically significant inverse association between resistin levels and MM (odds ratio, 0.44; 95% confidence interval (CI) 0.24-0.83 and 0.54; 95% CI 0.29-0.99, for the third and fourth quartiles, respectively, vs the lowest quartile; Ptrend=0.03). No association was observed for women.

CONCLUSIONS:

This study provides the first prospective evidence that low circulating resistin levels may be associated with an increased risk of MM, particularly for men.

• Authors: Loredana Santo, Lauren R Teras, Graham G Giles, Stephanie J Weinstein, Demetrius Albanes, Ye Wang, Ruth M Pfeiffer, Qing Lan, Nathaniel Rothman, Brenda M Birmann, Graham A Colditz, Michael N Pollak, Mark P Purdue, Jonathan N Hofmann
• Journal: British journal of cancer (Br J Cancer) Vol. 117 Issue 8 Pg. 1241-1245 (Oct 10 2017) ISSN: 1532-1827 [Electronic] England
• PMID: 28829767 (Publication Type: Journal Article)

Chemical References

• ADIPOQ protein, human
• Adiponectin
• RETN protein, human
• Resistin

Topics

• Adiponectin (blood)
• Aged
• Australia (epidemiology)
• Case-Control Studies
• Cohort Studies
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Incidence
• Male
• Middle Aged
• Multiple Myeloma (blood, epidemiology)
• Multivariate Analysis
• Odds Ratio
• Prospective Studies
• Resistin (blood)
• Risk
• Sex Factors
• United States (epidemiology)