Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody.

Abstract

The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions. Morbid obesity was seen in 88% (7/8) of children of Caribbean origin. As endocrinopathies were prevalent in the majority of paediatric-onset AQP4-Ab NMOSD, endocrine surveillance and in particular early aggressive weight management is required for patients with AQP4-Ab NMOSD.

• Authors: Yael Hacohen, Silvia Messina, Hoong-Wei Gan, Sukhvir Wright, Saleel Chandratre, Maria Isabel Leite, Penny Fallon, Angela Vincent, Olga Ciccarelli, Evangeline Wassmer, Ming Lim, Jacqueline Palace, Cheryl Hemingway
• Journal: Multiple sclerosis (Houndmills, Basingstoke, England) (Mult Scler) Vol. 24 Issue 5 Pg. 679-684 (04 2018) ISSN: 1477-0970 [Electronic] England
• PMID: 28803524 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aquaporin 4
• Autoantibodies
• Immunologic Factors

Topics

• Adolescent
• Amenorrhea (epidemiology, etiology)
• Aquaporin 4 (immunology)
• Autoantibodies
• Caribbean Region (epidemiology)
• Child
• Cohort Studies
• Endocrine System Diseases (epidemiology, etiology)
• Female
• Humans
• Hyperandrogenism (epidemiology, etiology)
• Hyperinsulinism (epidemiology, etiology)
• Hyponatremia (epidemiology, etiology)
• Hypothalamus (diagnostic imaging, pathology)
• Hypothyroidism (epidemiology, etiology)
• Immunologic Factors
• Magnetic Resonance Imaging
• Male
• Morbidity
• Neuromyelitis Optica (complications, diagnostic imaging, epidemiology, immunology)
• Obesity, Morbid (epidemiology, etiology)
• Prevalence
• Quality of Life