Abstract | BACKGROUND: METHODS: This study included 26 uremic patients who had undergone percutaneous coronary intervention in China-Japan Friendship Hospital from November 2015 to May 2017. We examined their thromboelastography results before and after hemodialysis. Self-paired t-tests were employed to analyze changes in the inhibition rate of platelet aggregation. RESULTS: The mean inhibition rates of arachidonic acid-induced platelet aggregation before and after hemodialysis were 82.56 ± 2.79% and 86.42 ± 3.32%, respectively (t= -1.278, P= 0.213). The mean inhibition rates of adenosine diphosphate-induced platelet aggregation before and after hemodialysis were 67.87 ± 5.10% and 61.94 ± 5.90%, respectively (t = 1.425, P= 0.167). There was no significant difference in the inhibition rates of platelet aggregation before or after hemodialysis. These results also applied to patients with different sensitivity to aspirin and clopidogrel. CONCLUSION:
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Authors | Dong-Liang Fu, Ting-Ting Zhao, Wen-Hua Peng, Peng Yang, Xiao-Fei Liu, Hu Zhang, Xian-Lun Li, Yong Wang, Jin-Gang Zheng, Yan-Xiang Gao, Hong-Kai Lu, Qi Wang |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 130
Issue 16
Pg. 1914-1918
(Aug 20 2017)
ISSN: 2542-5641 [Electronic] China |
PMID | 28776542
(Publication Type: Journal Article)
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Chemical References |
- Platelet Aggregation Inhibitors
- Clopidogrel
- Ticlopidine
- Aspirin
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Topics |
- Aged
- Aspirin
(therapeutic use)
- Clopidogrel
- Coronary Disease
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Platelet Aggregation
(drug effects)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Renal Dialysis
- Thrombelastography
- Ticlopidine
(analogs & derivatives, therapeutic use)
- Uremia
(drug therapy)
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