Small airway bronchodilator response to different doses of salbutamol in 7-year-old children.

Abstract

The Global Initiative for Asthma (GINA) guidelines do not specify a bronchodilator range for bronchodilator response (BDR) testing and simply recommend a salbutamol dose of 200 to 400 μg. We determined the oscillometric BDR results of children given low-dose (2 puffs, 200 μg) and standard-dose (4 puffs, 400 μg) salbutamol to compare the small airway responses of healthy controls (defined using criteria based on the guidelines developed at the American Thoracic Society) and exclusion subjects (defined as any child that did not meet the inclusion criteria for healthy controls). The oscillometric reactance of small airways is significantly associated with the dose of salbutamol used for BDR testing in exclusion children. We suggest use of the standard-dose of salbutamol for oscillometric BDR testing.

• Authors: Dong Keon Yon, Hye Mi Jee, Eun Kyo Ha, Seung Jin Lee, Young-Ho Jung, Kyung Suk Lee, Man Yong Han
• Journal: Respiratory research (Respir Res) Vol. 18 Issue 1 Pg. 148 (08 03 2017) ISSN: 1465-993X [Electronic] England
• PMID: 28774310 (Publication Type: Letter, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Bronchodilator Agents
• Albuterol

Topics

• Albuterol (administration & dosage)
• Bronchodilator Agents (administration & dosage)
• Child
• Dose-Response Relationship, Drug
• Female
• Humans
• Lung (drug effects, physiology)
• Male
• Oscillometry (methods)
• Prospective Studies
• Single-Blind Method