Abstract | INTRODUCTION: Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. However, the role of the mitochondrial assembly receptor in the prognosis of cancer patients remains unclear. The aim of this study was to evaluate the significance of mitochondrial assembly receptor signaling in the prognosis of oral tongue squamous cell carcinoma. METHODS: RESULTS: Mitochondrial assembly receptor overexpression was significantly correlated with early pathological T classification ( p=0.029) and the absence of extracapsular spread ( p=0.039). Univariate analyses demonstrated that mitochondrial assembly receptor overexpression was significantly associated with superior overall survival ( p=0.012). In multivariate comparison, mitochondrial assembly receptor overexpression remained independently associated with superior overall survival ( p=0.008, hazard ratio=1.862). In vitro, angiotensin-(1-7) suppressed the cell growth in oral tongue squamous cell carcinoma cells, and this response was reversed by the mitochondrial assembly receptor antagonist, A779. CONCLUSION:
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Authors | Yan-Ye Su, Chang-Han Chen, Chih-Yen Chien, Wei-Che Lin, Wan-Ting Huang, Shau-Hsuan Li |
Journal | Journal of the renin-angiotensin-aldosterone system : JRAAS
(J Renin Angiotensin Aldosterone Syst)
2017 Jul-Sep
Vol. 18
Issue 3
Pg. 1470320317717904
ISSN: 1752-8976 [Electronic] England |
PMID | 28747140
(Publication Type: Journal Article)
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Chemical References |
- MAS1 protein, human
- Peptide Fragments
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Receptors, G-Protein-Coupled
- Angiotensin I
- angiotensin I (1-7)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Angiotensin I
(metabolism)
- Carcinoma, Squamous Cell
(metabolism, pathology)
- Cell Line, Tumor
- Cell Proliferation
- Female
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Peptide Fragments
(metabolism)
- Prognosis
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
(antagonists & inhibitors, metabolism)
- Receptors, G-Protein-Coupled
(antagonists & inhibitors, metabolism)
- Tongue Neoplasms
(metabolism, pathology)
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