angiotensin I (1-7)

Also Known As:

Ang I (1-7); TXA-127; TXA127; angiotensin (1-7); angiotensin 1-7; angiotensin II (1-7); angiotensin II (1-7) heptapeptide; angiotensin II-(1-7); angiotensin-(1-7); angiotensin-I (1-7)

Networked: 693 relevant articles (40 outcomes, 74 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Santos, Robson A S: 27 articles (01/2022 - 05/2002)
2.	Ferrario, Carlos M: 19 articles (01/2020 - 04/2002)
3.	Gallagher, Patricia E: 19 articles (10/2017 - 04/2004)
4.	Bader, Michael: 17 articles (01/2021 - 05/2002)
5.	Zhang, Cheng: 14 articles (03/2022 - 07/2008)
6.	Chappell, Mark C: 13 articles (12/2020 - 10/2003)
7.	Tallant, E Ann: 13 articles (10/2017 - 11/2004)
8.	Walther, Thomas: 12 articles (03/2022 - 08/2008)
9.	Oudit, Gavin Y: 12 articles (01/2020 - 12/2008)
10.	Zhang, Yun: 11 articles (03/2022 - 07/2008)

Related Diseases

1.	Inflammation (Inflammations) 09/22/2023 - "This study aims to investigate whether SARS-CoV-2 SP can induce inflammation through ACE2 in the alveolar epithelial cells which can be modulated through angiotensin-(1-7)/Mas receptor axis. " 12/01/2013 - "Recent studies suggest that RAS blockers may reduce inflammation by increasing endogenous concentrations of the anti-inflammatory heptapeptide angiotensin-(1-7) [Ang-(1-7)]. " 10/01/2021 - "Overall, biochips exhibited processes of cell proliferation and inflammation (via TGFB1) coupled with anti-fibrotic signaling (via angiotensin 1-7, ATR-2, and MASR). " 01/01/2021 - "Angiotensin-(1-7) [Ang-(1-7)] is a pro-resolving mediator that acts on its Mas receptor (MasR) to promote resolution of inflammation. " 01/01/2020 - "Central angiotensin-(1-7) attenuates systemic inflammation via activation of sympathetic signaling in endotoxemic rats."
2.	Hypertension (High Blood Pressure) 10/30/2019 - "Reduced NO levels may reduce the formation of angiotensin 1-7 dampening the cardio-protective effects of the renin-angiotensin system contributing to resistant hypertension. " 12/01/2021 - "This study investigated the impact of intrarenal angiotensin 1-7 (Ang [1-7]) infusion on renal excretory function in a rat model of hypertension. " 01/01/2021 - "Previous data showed hypertensive rats subjected to chronic intracerebroventricular (ICV) infusion of angiotensin-(1-7) presented attenuation of arterial hypertension, improvement of baroreflex sensitivity, restoration of cardiac autonomic balance and a shift of cardiac renin-angiotensin system (RAS) balance toward Ang-(1-7)/Mas receptor. " 05/01/2015 - "In experimental animal models of hypertension, angiotensin (1-7) [ANG-(1-7)] is higher in females compared with males; however, it is less clear whether the same applies to humans. " 09/01/2014 - "Angiotensin-(1-7) as a strategy in the treatment of hypertension?"
3.	Fibrosis (Cirrhosis) 06/01/2012 - "In contrast, in recent studies, angiotensin-(1-7) [Ang-(1-7)] has been shown to antagonize fibrosis. " 04/01/2012 - "Previous studies showed that angiotensin-(1-7) [Ang-(1-7)] attenuates cardiac remodeling by reducing both interstitial and perivascular fibrosis. " 06/01/2019 - "Protective Effect of Angiotensin (1-7) on Silicotic Fibrosis in Rats." 01/01/2019 - "We conclude that in addition to MasR, MrgD, a newly discovered receptor for Angiotensin-(1-7), plays a key role in splanchnic vasodilatation in cirrhosis. " 01/01/2019 - "Unique mechanistic insights into the beneficial effects of angiotensin-(1-7) on the prevention of cardiac fibrosis: A metabolomic analysis of primary cardiac fibroblasts."
4.	Cardiovascular Diseases (Cardiovascular Disease) 05/13/2008 - "The pharmacodynamic profile of angiotensin-(1-7) is rather complex, and in vitro and in vivo studies demonstrated a wide palette of effects for angiotensin-(1-7), some of them potentially beneficial for cardiovascular disease. " 01/01/2021 - "ACE2 regulates the local actions of the renin-angiotensin system in cardiovascular tissues, and the ACE2/Angiotensin 1-7 axis exerts protective actions in cardiovascular disease. " 04/01/2016 - "The present review focuses on angiotensin-(1-7)/Mas axis as a promising target to attenuate the physiological response to emotional stress reducing the risk of cardiovascular diseases. " 01/01/2014 - "Low angiotensin-(1-7) (Ang-(1-7)) concentration is observed in some cardiovascular diseases and exercise training seems to restore its concentration in the heart. " 05/01/2010 - "The renin-angiotensin system (RAS) is nowadays an important target in cardiovascular diseases and we are currently on the verge of a new interpretation of its role in cardiovascular homeostasis, mainly due to the identification of the new axis ACE2/angiotensin 1 - 7/Mas receptor. "
5.	Insulin Resistance 02/01/2020 - "Angiotensin-(1-7) Participates in Enhanced Skeletal Muscle Insulin Sensitivity After a Bout of Exercise." 01/01/2020 - "Potential role of angiotensin-(1-7) in the improvement of vascular insulin sensitivity after a bout of exercise." 05/01/2016 - "Chronic Angiotensin-(1-7) Improves Insulin Sensitivity in High-Fat Fed Mice Independent of Blood Pressure." 01/01/2016 - "Does exercise increase insulin sensitivity through angiotensin 1-7?" 03/01/2014 - "Heat shock prevents insulin resistance-induced vascular complications by augmenting angiotensin-(1-7) signaling."

Related Drugs and Biologics

1.	Angiotensin II
2.	Peptides (Polypeptides)
3.	Angiotensin-Converting Enzyme 2
4.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
5.	Peptide Hydrolases (Proteases)
6.	Angiotensins
7.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
8.	Glucose (Dextrose)
9.	Streptozocin (Streptozotocin)
10.	Peptide Hormones (Polypeptide Hormones)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Intraventricular Infusions
4.	Ovariectomy (Oophorectomy)
5.	Surgical Instruments (Clip)