Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study.

Abstract

BACKGROUND:

Adipose tissue is an abundant source of mesenchymal stem cells, called adipose-derived stem cells, which have anti-inflammatory and trophic effects to enhance overall tissue repair.

OBJECTIVE:

To determine the healing effects of autologous adipose tissue graft on hypertensive leg ulcers.

METHODS:

Prospective pilot study in 1 French dermatology department. Ten patients with a hypertensive leg ulcer were enrolled from April 2013 to June 2015. The primary end point was the wound closure rate at each follow-up visit. The secondary end points were wound characteristics, pain assessment and adverse events.

RESULTS:

One patient, the only smoker, was lost to follow-up at month 5 (M5). For the 9 non-smokers, wound surfaces constantly and significantly decreased: the median wound closure rate was 73.2% at M3 and 93.1% at M6, p < 0.001. The median wound closure rate of the 10 patients was 63.2% at M3, p < 0.001. Percentages of fibrin and necrosis decreased, granulation tissue increased significantly. Pain rapidly and significantly decreased. No recurrence or adverse event was observed.

CONCLUSION:

Our data suggest that autologous adipose tissue grafting induces pain relief and promotes wound healing with a good skin quality. Large prospective controlled randomized studies are required to confirm these results.

• Authors: M Chopinaud, D Labbé, C Creveuil, M Marc, H Bénateau, B Mourgeon, E Chopinaud, A Veyssière, A Dompmartin
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 233 Issue 2-3 Pg. 234-241 ( 2017) ISSN: 1421-9832 [Electronic] Switzerland
• PMID: 28746927 (Publication Type: Journal Article)
• Copyright: © 2017 S. Karger AG, Basel.

Topics

• Adipose Tissue (transplantation)
• Aged
• Aged, 80 and over
• Female
• Humans
• Hypertension (complications)
• Leg Ulcer (etiology, surgery)
• Male
• Middle Aged
• Pain (etiology)
• Pain Measurement
• Pilot Projects
• Prospective Studies
• Transplantation, Autologous (adverse effects)
• Wound Healing